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Authordc.contributor.authorRegan, Jennifer C. 
Authordc.contributor.authorConcha, Miguel L. 
Authordc.contributor.authorRoussigne, Myriam 
Authordc.contributor.authorRussell, Claire 
Authordc.contributor.authorWilson, Stephen W. 
Admission datedc.date.accessioned2019-03-11T12:56:48Z
Available datedc.date.available2019-03-11T12:56:48Z
Publication datedc.date.issued2009
Cita de ítemdc.identifier.citationNeuron, Volumen 61, Issue 1, 2018, Pages 27-34
Identifierdc.identifier.issn08966273
Identifierdc.identifier.other10.1016/j.neuron.2008.11.030
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/164670
Abstractdc.description.abstractNeuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated by the failure of the parapineal nucleus to migrate from its initial midline position to the left side of the brain. Local provision of Fgf8 restores the asymmetric migration of parapineal cells, usually to the left, irrespective of the location of the Fgf8 source. This laterality bias is due to left-sided Nodal signaling and when the bias in Nodal signaling is removed, parapineal cells migrate toward the source of Fgf8 protein. This study presents a mechanism for breaking neuroanatomical symmetry through Fgf8-dependent regulation of bistable left- or right-sided migration of the parapineal. The combined action of Fgf and Nodal signals ensures the establishment of neuroanatomical asymmetries with consistent laterality. © 2009 Elsevier Inc. All rights reserved.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceNeuron
Keywordsdc.subjectDEVBIO
Keywordsdc.subjectMOLNEURO
Keywordsdc.subjectSIGNALING
Títulodc.titleAn Fgf8-Dependent Bistable Cell Migratory Event Establishes CNS Asymmetry
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile