Mostrar el registro sencillo del ítem

Autordc.contributor.authorMiranda, H. F. 
Autordc.contributor.authorSierralta, F. 
Autordc.contributor.authorPrieto, J. C. 
Fecha ingresodc.date.accessioned2019-03-11T12:56:53Z
Fecha disponibledc.date.available2019-03-11T12:56:53Z
Fecha de publicacióndc.date.issued2009
Cita de ítemdc.identifier.citationPharmacology Biochemistry and Behavior, Volumen 92, Issue 2, 2018, Pages 314-318
Identificadordc.identifier.issn00913057
Identificadordc.identifier.other10.1016/j.pbb.2008.12.018
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/164691
Resumendc.description.abstractOpioids and non-steroidal anti-inflammatory drugs (NSAIDs) are used to relieve acute and chronic pain. The purpose of this study was to determine the degree of interaction between dexketoprofen and NSAID examples of COXs inhibitors using the isobolographic analysis in the formalin orofacial test in mice. The drugs, i.p., induced a dose-dependent antinociception with different potencies in both test phases. Combinations of dexketoprofen with naproxen, nimesulide, ibuprofen or paracetamol on the basis of the fixed ratio (1:1) of their ED50's values alone demonstrated synergism in both phases. This is important since the orofacial pain is a test not currently used in mice; the drugs are all analgesic for humans and phase II is representative of inflammatory pain. The synergism was: COX-3 > COX-2 > COX-1 inhibitors, this is particularly interesting since the inhibitor of COX-3, paracetamol, displayed a robust anti-inflammatory activity in an assay of acute and inflammatory pain that mimics
Idiomadc.language.isoen
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourcePharmacology Biochemistry and Behavior
Palabras clavesdc.subjectAcute pain
Palabras clavesdc.subjectDexketoprofen
Palabras clavesdc.subjectInflammatory pain
Palabras clavesdc.subjectNSAIDs
Palabras clavesdc.subjectOrofacial pain
Palabras clavesdc.subjectSynergism
Títulodc.titleSynergism between NSAIDs in the orofacial formalin test in mice
Tipo de documentodc.typeArtículo de revista
Catalogadoruchile.catalogadorSCOPUS
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Descargar archivo

Icon

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivs 3.0 Chile
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivs 3.0 Chile