Melatonin reduces cortisol response to ACTH in humans La melatonina reduce la respuesta de cortisol al ACTH en humanos
Author
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Campino, Carmen
Author
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Valenzuela, Francisco
Author
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Arteaga, Eugenio
Author
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Torres Farfán, Claudia
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Trucco, Cristián
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Velasco, Alfredo
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Guzmán, Sergio
Author
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Serón Ferré, María
Admission date
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2019-03-11T12:57:24Z
Available date
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2019-03-11T12:57:24Z
Publication date
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2008
Cita de ítem
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Revista Medica de Chile, Volumen 136, Issue 11, 2018, Pages 1390-1397
Identifier
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00349887
Identifier
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07176163
Identifier
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https://repositorio.uchile.cl/handle/2250/164711
Abstract
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Background: Melatonin receptors are widely distributed in human tissues but they have not been reported in human adrenal gland. Aim: To assess if the human adrenal gland expresses melatonin receptors and if melatonin affects cortisol response to ACTH in dexamethasone suppressed volunteers. Material and methods: Adrenal glands were obtained from 4 patients undergoing unilateral nephrectomy-adrenalectomy for renal cancer. Expression of mRNA MT1 and MT2 melatonin receptors was measured by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). The effect of melatonin on the response to intravenous (i.v.) ACTH was tested (randomized cross-over, double-blind, placebo-controlled trial) in eight young healthy males pretreated with dexamethasone (1 mg) at 23:00 h. On the next day, at 08:00 h, an i.v. line was inserted, at 08:30 h, and after a blood sample, subjects ingested 6 mg melatonin or placebo. At 09:00 h, 1-24 ACTH (Cortrosyn, 1 μg/1.73 m2 body surface area) was injected, drawing samp