Effects of tramadol and dexketoprofen on analgesia and gastrointestinal transit in mice
Author
dc.contributor.author
Miranda, H. F.
Author
dc.contributor.author
Puig, M. M.
Author
dc.contributor.author
Romero, M. A.
Author
dc.contributor.author
Prieto, J. C.
Admission date
dc.date.accessioned
2019-03-11T12:57:25Z
Available date
dc.date.available
2019-03-11T12:57:25Z
Publication date
dc.date.issued
2009
Cita de ítem
dc.identifier.citation
Fundamental and Clinical Pharmacology, Volumen 23, Issue 1, 2018, Pages 81-88
Identifier
dc.identifier.issn
07673981
Identifier
dc.identifier.issn
14728206
Identifier
dc.identifier.other
10.1111/j.1472-8206.2008.00636.x
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/164720
Abstract
dc.description.abstract
The purpose of the present study was to evaluate the nature of the antinociceptive interaction among dexketoprofen (DEX), a mixed inhibitor of the cyclo-oxygenases, and tramadol (TRAM), a weak opioid with monoaminergic activity that inhibits norepinephrine and serotonin re-uptake. We assessed antinociception in the acetic acid writhing test, the tail flick and the formalin (FT) tests, and gastrointestinal transit (GIT) after the administration of a charcoal meal. The analysis of the interaction was carried out using isobolograms and interaction indexes or the fixed-dose method GIT. The administration of DEX or TRAM individually induced dose-dependent antinociception in all the algesiometric tests. In the three tests, TRAM was between 5.2 (FT, phase I) and 35 times (FT, Phase II) more potent than DEX. When testing combinations at different potency ratios (1 : 1, 1 : 3, 3 : 1), we could demonstrate synergy in all algesiometric tests, only when drugs were combined in a 1 : 1 proportion. I