Psychological adaptation in children with idiopathic short stature treated with growth hormone or placebo
Author
dc.contributor.author
Ross, Judith L.
Author
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Sandberg, David E.
Author
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Rose, Susan R.
Author
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Leschek, Ellen Werber
Author
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Baron, Jeffrey
Author
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Chipman, John J.
Author
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Cassorla Goluboff, Fernando
Author
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Quigley, Charmian A.
Author
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Crowe, Brenda J.
Author
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Roberts, Kristen
Author
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Cutler, Gordon B., Jr.
Admission date
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2019-03-11T12:57:25Z
Available date
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2019-03-11T12:57:25Z
Publication date
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2004
Cita de ítem
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Journal of Clinical Endocrinology and Metabolism, Volumen 89, Issue 10, 2018, Pages 4873-4878
Identifier
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0021972X
Identifier
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10.1210/jc.2004-0791
Identifier
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https://repositorio.uchile.cl/handle/2250/164722
Abstract
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The influence of short stature on psychological adaptation in childhood and adolescence is controversial. GH is currently used to treat children with idiopathic short stature (ISS, also known as non-GH-deficient short stature). This study represents the first double-blind, placebo-controlled trial of the effects of GH on the psychological adaptation of children and adolescents with ISS, treated with GH until adult height was attained. Sixty-eight children (53 males, 15 females), 9-16 yr old, with marked ISS (measured height or predicted adult height -2.5 SD or less) received either GH 0.074 mg/kg or placebo sc three times per week until height velocity decreased to less than 1.5 cm/yr. Parents completed the Child Behavior Checklist (CBCL) and children the Self-Perception Profile (SPP) and Silhouette Apperception Technique at baseline and annually thereafter. Baseline behavioral/emotional adjustment (CBCL) and self-concept (SPP) scores for children with ISS were within the normative ran