Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome
Author
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Sir Petermann, Teresa
Author
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Codner Dujovne, Ethel
Author
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Pérez, Virginia
Author
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Echiburú López, Bárbara
Author
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Maliqueo Yevilao, Manuel
Author
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Ladrón de Guevara, Amanda
Author
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Preisler, Jessica
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Crisosto King, Nicolás
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Sánchez, Fernando
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Cassorla Goluboff, Fernando
Author
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Bhasin, Shalender
Admission date
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2019-03-11T12:57:33Z
Available date
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2019-03-11T12:57:33Z
Publication date
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2009
Cita de ítem
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Journal of Clinical Endocrinology and Metabolism, Volumen 94, Issue 6, 2018, Pages 1923-1930
Identifier
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0021972X
Identifier
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0021972X
Identifier
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10.1210/jc.2008-2836
Identifier
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https://repositorio.uchile.cl/handle/2250/164768
Abstract
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Context: A significant proportion of the first-degree female relatives of women with polycystic ovary syndrome (PCOS) may be at risk for developing PCOS. However, it is not known at which stage of pubertal development the hormonal and metabolic abnormalities ensue in PCOS. Objective: The aim of the study was to assess the reproductive and metabolic profiles of daughters of women with PCOS (PCOSd) during the peripubertal period, a stage during which the gonadal axis is activated and PCOS may become clinically manifest. Design: Ninety-nine PCOSd [30 prepubertal and 69 pubertal (Tanner II-V)] and 84 daughters of control women (Cd) (20 prepubertal and 64 pubertal) were studied. An oral glucose tolerance test, a GnRH agonist test (leuprolide acetate, 10 μg/kg sc), and a transabdominal ultrasound were performed. Gonadotropins, sex steroids, SHBG, glucose, insulin, and lipids were determined. Results: Both groups had similar chronological ages and body mass index SD scores according to Tanner