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Author | dc.contributor.author | Cáceres, Dante D. | |
Author | dc.contributor.author | Quiñones, Luis A. | |
Author | dc.contributor.author | Schroeder, Jane C. | |
Author | dc.contributor.author | Gil, Leonel D. | |
Author | dc.contributor.author | Irarrázabal, Carlos E. | |
Admission date | dc.date.accessioned | 2019-03-11T12:57:37Z | |
Available date | dc.date.available | 2019-03-11T12:57:37Z | |
Publication date | dc.date.issued | 2009 | |
Cita de ítem | dc.identifier.citation | Lung, Volumen 187, Issue 2, 2018, Pages 110-115 | |
Identifier | dc.identifier.issn | 03412040 | |
Identifier | dc.identifier.other | 10.1007/s00408-008-9133-3 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/164780 | |
Abstract | dc.description.abstract | Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G × E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR) using an adjusted unconditional logistic model. We found a significant and positive interaction association between Proallele carriers and smoking habits in both case-control and case-only designs: IOR = 3.90 (95% confidence interval [CI] = 1.10-13.81) and 3.05 (95% CI = 1.63-5.72), respectively. These exploratory results suggest a synergistic effect of the smoking habit and the susceptibility of the Pro allele on lung cancer risk compared with each risk factor alone. © 2008 Springer Science+Business Media, LLC. | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Lung | |
Keywords | dc.subject | Case control | |
Keywords | dc.subject | Case only | |
Keywords | dc.subject | Gene-environment interaction | |
Keywords | dc.subject | Genetic polymorphisms | |
Keywords | dc.subject | Lung cancer | |
Keywords | dc.subject | Risk effect modification | |
Keywords | dc.subject | Synergistic effect | |
Título | dc.title | Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile