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Authordc.contributor.authorSapag, Amalia 
Authordc.contributor.authorGonzález Martínez, Ginez Andrés 
Authordc.contributor.authorLobos González, Lorena 
Authordc.contributor.authorEncina, Gonzalo 
Authordc.contributor.authorTampier de Jong, Lutske 
Authordc.contributor.authorIsrael Jacard, Yedy 
Authordc.contributor.authorQuintanilla González, María Elena 
Admission datedc.date.accessioned2019-03-11T12:57:41Z
Available datedc.date.available2019-03-11T12:57:41Z
Publication datedc.date.issued2009
Cita de ítemdc.identifier.citationPharmacogenetics and Genomics, Volumen 19, Issue 7, 2018, Pages 528-537
Identifierdc.identifier.issn17446872
Identifierdc.identifier.issn17446880
Identifierdc.identifier.other10.1097/FPC.0b013e32832dc12a
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/164803
Abstractdc.description.abstractOBJECTIVE: Alcohol is detoxified in the liver by oxidizing enzymes that require nicotinamide adenine dinucleotide (NAD) such that, in the rat, the availability of NAD contributes to control voluntary ethanol intake. The UChA and UChB lines of Wistar rats drink low and high amounts of ethanol respectively and differ in the capacity of their mitochondria to oxidize NADH into NAD. This function resides in complex I of the respiratory chain and its variation is linked to genes transmitted through the maternal line. The aim of this study was to identify the genetic basis for the difference in the reoxidation of NADH in these nondrinker (UChA) and drinker (UChB) rats. METHODS: Seven mitochondrial genes and two chromosome X genes encoding complex I subunits from rats of both lineages were amplified from liver DNA and sequenced. RESULTS: The UChA and UChB rat lines differ in their Nd2, Nd4, Nd5 and Nd6 mitochondrial genes and in the encoded proteins. Most noteworthy are ND2 and ND4 whose amino
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePharmacogenetics and Genomics
Keywordsdc.subjectAlcohol preference
Keywordsdc.subjectComplex I
Keywordsdc.subjectMitochondrial genes
Keywordsdc.subjectNAD+
Keywordsdc.subjectND2
Keywordsdc.subjectND4
Keywordsdc.subjectND5
Keywordsdc.subjectND6
Keywordsdc.subjectPolymorphisms
Keywordsdc.subjectUChA and UChB rats
Títulodc.titlePolymorphisms in mitochondrial genes encoding complex i subunits are maternal factors of voluntary alcohol consumption in the rat
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile