Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS)
Author | dc.contributor.author | Miranda, Hugo F. | |
Author | dc.contributor.author | Pinardi, Hugo F. | |
Admission date | dc.date.accessioned | 2019-03-11T12:57:41Z | |
Available date | dc.date.available | 2019-03-11T12:57:41Z | |
Publication date | dc.date.issued | 2009 | |
Cita de ítem | dc.identifier.citation | Journal of Physiology and Pharmacology, Volumen 60, Issue 2, 2018, Pages 71-76 | |
Identifier | dc.identifier.issn | 08675910 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/164805 | |
Abstract | dc.description.abstract | To enhance analgesia, combination of analgesics drugs of proven efficacy is a strategy which is accompanied by a reduction of adverse effects. The present study was undertaken to characterize the antinociceptive interaction of morphine with different non-steroidal anti-inflammatory drugs (NSAIDs) using isobolographic analysis and the writhing test of mice. One of the possible mechanisms of action of spinally administered morphine with non-steroidal antiinflammatory drugs was investigated using the DOR antagonist naltrindole. The study demonstrated a synergistic antinociception of spinal administered combinations of morphine with the following NSAIDs agents: diclofenac, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam. The supraadditive effect seems to be independent of the selectivity of each NSAIDs to inhibit COX-1 or COX-2. The findings of the present work suggest that the combinations of opioids and non-steroidal anti-inflammatory drugs have a direct a | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Journal of Physiology and Pharmacology | |
Keywords | dc.subject | Antinociception | |
Keywords | dc.subject | COXs inhibitors | |
Keywords | dc.subject | Isobolographic analysis | |
Keywords | dc.subject | Morphine | |
Keywords | dc.subject | Naltrindole | |
Keywords | dc.subject | Writhing test | |
Título | dc.title | Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS) | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI |
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