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Autordc.contributor.authorPonce, Carlos 
Autordc.contributor.authorTorres, Marisa 
Autordc.contributor.authorGalleguillos, Carolina 
Autordc.contributor.authorSovino, Hugo 
Autordc.contributor.authorBoric Scarpa, María Angélica 
Autordc.contributor.authorFuentes, Ariel 
Autordc.contributor.authorJohnson, M. Cecilia 
Fecha ingresodc.date.accessioned2019-03-11T12:58:06Z
Fecha disponibledc.date.available2019-03-11T12:58:06Z
Fecha de publicacióndc.date.issued2009
Cita de ítemdc.identifier.citationReproduction, Volumen 137, Issue 4, 2018, Pages 727-737
Identificadordc.identifier.issn14701626
Identificadordc.identifier.issn17417899
Identificadordc.identifier.other10.1530/REP-08-0407
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/164811
Resumendc.description.abstractIn order to investigate the role of the nuclear factor κB (NFKB) pathway on gene expression in the eutopic endometrium in endometriosis, and in particular of interleukin-6 (IL6), we evaluated RELA, IκB kinase (CHUK), NFKBIA and IL6 expressions and NFKB DNA binding in eutopic endometrium from women with endometriosis. Eutopic endometrium was obtained from 37 women with endometriosis and 42 fertile women during laparoscopy. We analysed RELA, CHUK, NFKBIA and IL6 mRNA levels (RT-PCR); RELA, CHUK and NFKBIA proteins and p-NFKBIA/NFKBIA ratio (western blot); and NFKB binding (DNA shift assay) and IL6 concentration (ELISA) in endometrial explants. Our results indicate that mRNA and cytoplasmic proteins of RELA and CHUK exhibit constant levels in normal endometrium during the menstrual cycle. A dramatic increase (P<0.05) in NFKBIA mRNA expression, RELA nuclear presence and the mRNA and the protein of IL6 during late secretory phase was also observed in this tissue. By contrast, in eutopic end
Idiomadc.language.isoen
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourceReproduction
Palabras clavesdc.subjectReproductive Medicine
Palabras clavesdc.subjectEmbryology
Palabras clavesdc.subjectEndocrinology
Palabras clavesdc.subjectObstetrics and Gynecology
Palabras clavesdc.subjectCell Biology
Títulodc.titleNuclear factor κB pathway and interleukin-6 are affected in eutopic endometrium of women with endometriosis
Tipo de documentodc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogadoruchile.catalogadorSCOPUS
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivs 3.0 Chile