Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes
Author
dc.contributor.author
Blondel, Carlos J.
Author
dc.contributor.author
Jiménez, Juan C.
Author
dc.contributor.author
Contreras, Inés
Author
dc.contributor.author
Santiviago, Carlos A.
Admission date
dc.date.accessioned
2019-03-11T12:58:09Z
Available date
dc.date.available
2019-03-11T12:58:09Z
Publication date
dc.date.issued
2009
Cita de ítem
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BMC Genomics, Volumen 10,
Identifier
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14712164
Identifier
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10.1186/1471-2164-10-354
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/164823
Abstract
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Background: The recently described Type VI Secretion System (T6SS) represents a new paradigm of protein secretion in bacteria. A number of bioinformatic studies have been conducted to identify T6SS gene clusters in the available bacterial genome sequences. According to these studies, Salmonella harbors a unique T6SS encoded in the Salmonella Pathogenicity Island 6 (SPI-6). Since these studies only considered few Salmonella genomes, the present work aimed to identify novel T6SS loci by in silico analysis of every genome sequence of Salmonella available. Results: The analysis of sequencing data from 44 completed or in progress Salmonella genome projects allowed the identification of 3 novel T6SS loci. These clusters are located in differentially-distributed genomic islands we designated SPI-19, SPI-20 and SPI-21, respectively. SPI-19 was identified in a subset of S. enterica serotypes including Dublin, Weltevreden, Agona, Gallinarum and Enteritidis. In the later, an internal deletion eli