Differences in expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender
Author
dc.contributor.author
Mericq, Verónica
Author
dc.contributor.author
Medina, P.
Author
dc.contributor.author
Kakarieka, E.
Author
dc.contributor.author
Márquez, L.
Author
dc.contributor.author
Johnson, M. C.
Author
dc.contributor.author
Iñíguez Vila, Germán
Admission date
dc.date.accessioned
2019-03-11T12:58:12Z
Available date
dc.date.available
2019-03-11T12:58:12Z
Publication date
dc.date.issued
2009
Cita de ítem
dc.identifier.citation
European Journal of Endocrinology, Volumen 161, Issue 3, 2018, Pages 419-425
Identifier
dc.identifier.issn
08044643
Identifier
dc.identifier.issn
1479683X
Identifier
dc.identifier.other
10.1530/EJE-09-0308
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/164838
Abstract
dc.description.abstract
Background: Fetal exposure to maternal glucocorticoids may determine fetal growth and the programing of later disorders. Availability of the glucocorticoids in the placenta is regulated by the 11β-hydroxysteroid dehydrogenase (11β-HSDs) enzymes. To date, there are discrepancies with regard to cortisol (F) cord blood levels in fetuses with intrauterine growth retardation in different species. Objective: To study the expression and activity of 11β-HSDs in placentas from full term small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA) newborns, and cortisol cord blood concentration. Methods: Twenty-five placentas from AGA, 24 SGA and 25 LGA were collected. Results: SGA newborns had significantly lower and LGA newborns had significantly higher birth weight, birth length, head circumference, and placental weight than AGA counterparts.We observed a direct correlation between placental weight and birth weight, birth length and head circumfer
Differences in expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender