Effect of interleukin-1β on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function
Author
dc.contributor.author
Constandil, Luis
Author
dc.contributor.author
Hernández, Alejandro
Author
dc.contributor.author
Pelissier Serrano, Teresa
Author
dc.contributor.author
Arriagada, Osvaldo
Author
dc.contributor.author
Espinoza, Karla
Author
dc.contributor.author
Burgos, Hector
Author
dc.contributor.author
Laurido, Claudio
Admission date
dc.date.accessioned
2019-03-11T12:58:12Z
Available date
dc.date.available
2019-03-11T12:58:12Z
Publication date
dc.date.issued
2009
Cita de ítem
dc.identifier.citation
Arthritis Research and Therapy, Volumen 11, Issue 4, 2018,
Identifier
dc.identifier.issn
14786354
Identifier
dc.identifier.issn
14786362
Identifier
dc.identifier.other
10.1186/ar2756
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/164842
Abstract
dc.description.abstract
Introduction: Cytokines produced by spinal cord glia after peripheral injuries have a relevant role in the maintenance of pain states. Thus, while IL-1β is overexpressed in the spinal cords of animals submitted to experimental arthritis and other chronic pain models, intrathecal administration of IL-1β to healthy animals induces hyperalgesia and allodynia and enhances wind-up activity in dorsal horn neurons. Methods: To investigate the functional contribution of glial cells in the spinal cord nociceptive transmission, the effect of intrathecally administered IL-1β was studied in both normal and adjuvant-induced arthritic rats with or without glial inhibition. Four weeks after induction of monoarthritis, rats were treated with the glial cell inhibitor propentofylline (10 μg i.t. daily during 10 days) and submitted to a C-fiber-mediated reflex paradigm evoked by single and repetitive (wind-up) electric stimulation. Results: Both the propentofylline treatment and the monoarthritic conditi