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Authordc.contributor.authorPino, M. 
Authordc.contributor.authorGalleguillos, C. 
Authordc.contributor.authorTorres, M. 
Authordc.contributor.authorSovino, H. 
Authordc.contributor.authorFuentes, A. 
Authordc.contributor.authorBoric Scarpa, María Angélica 
Authordc.contributor.authorJohnson, M. C. 
Admission datedc.date.accessioned2019-03-11T12:58:21Z
Available datedc.date.available2019-03-11T12:58:21Z
Publication datedc.date.issued2009
Cita de ítemdc.identifier.citationReproduction, Volumen 138, Issue 5, 2018, Pages 837-847
Identifierdc.identifier.issn14701626
Identifierdc.identifier.issn17417899
Identifierdc.identifier.other10.1530/REP-09-0196
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/164885
Abstractdc.description.abstractEndometriosis is a benign gynecological pathology in which immune system deregulation may play a role in its initiation and progression. In endometriotic lesions, intercellular adhesion molecule-1 (ICAM1) is released from the cell membrane by proteolytic cleavage of its extracellular domain, a process that coincides with increased expression and proteolytic activity of metalloproteinases such as MMP1 and MMP9. The objective of our study was to investigate the association between MMP1 and MMP9 activities and ICAM1 cleavage mediated by tumor necrosis factor (TNF) in eutopic endometrial stromal cells from women with and without (control) endometriosis during culture. The RNA was evaluated by RT-PCR, and the protein was determined by western blot (ICAM1, MMP1), casein or gelatin zymographies (secreted active MMP1 or MMP9 respectively), ELISA (soluble ICAM1 (sICAM1)), and fluorescence assay (secreted active MMP1). Under basal conditions, proMMP9 dimer and MMP9 were higher in endometriosis c
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceReproduction
Keywordsdc.subjectObstetrics and Gynecology
Keywordsdc.subjectReproductive Medicine
Keywordsdc.subjectEmbryology
Keywordsdc.subjectEndocrinology
Keywordsdc.subjectCell Biology
Títulodc.titleAssociation between MMP1 and MMP9 activities and ICAM1 cleavage induced by tumor necrosis factor in stromal cell cultures from eutopic endometria of women with endometriosis
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile