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Authordc.contributor.authorMatus, Soledad 
Authordc.contributor.authorNassif, Melissa 
Authordc.contributor.authorGlimcher, Laurie H. 
Authordc.contributor.authorHetz Flores, Claudio 
Admission datedc.date.accessioned2019-03-11T12:59:05Z
Available datedc.date.available2019-03-11T12:59:05Z
Publication datedc.date.issued2009
Cita de ítemdc.identifier.citationAutophagy, Volumen 5, Issue 8, 2018, Pages 1226-1228
Identifierdc.identifier.issn15548635
Identifierdc.identifier.issn15548627
Identifierdc.identifier.other10.4161/auto.5.8.10247
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/164915
Abstractdc.description.abstractEndoplasmic reticulum (ER) stress has been extensively described in many protein misfolding disorders including amyotrophic lateral sclerosis (ALS). Adaptation to ER stress is mediated by the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). We have recently defined the contribution of X-Box binding protein-1 (XBP-1) to ALS, a key UPR transcription factor that regulates genes involved in protein folding and quality control. Despite expectations that XBP-1 deficiency would enhance the severity of experimental ALS, these mice were instead markedly more resistant to developing the disease. This phenotype was associated with enhanced clearance of abnormal protein aggregates by macroautophagy, a cellular pathway involved in lysosome-mediated protein degradation. Our results reveal a critical crosstalk between these two stress pathways that can provide protection against neurodegeneration. Here, we discuss possible signaling pathways that m
Lenguagedc.language.isoen
Publisherdc.publisherTaylor and Francis Inc.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceAutophagy
Keywordsdc.subjectAmyotrophic lateral sclerosis
Keywordsdc.subjectAutophagy
Keywordsdc.subjectER stress
Keywordsdc.subjectERAD
Keywordsdc.subjectUPR
Keywordsdc.subjectXBP-1
Títulodc.titleXBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile