Mostrar el registro sencillo del ítem

Autordc.contributor.authorMorales, Paola 
Autordc.contributor.authorSimola, Nicola 
Autordc.contributor.authorBustamante, Diego 
Autordc.contributor.authorLisboa, Francisco 
Autordc.contributor.authorFiedler, Jenny 
Autordc.contributor.authorGebicke Haerter, Peter J. 
Autordc.contributor.authorMorelli, Micaela 
Autordc.contributor.authorTasker, R. Andrew 
Autordc.contributor.authorHerrera-Marschitz Muller, Mario 
Fecha ingresodc.date.accessioned2019-03-11T12:59:19Z
Fecha disponibledc.date.available2019-03-11T12:59:19Z
Fecha de publicacióndc.date.issued2010
Cita de ítemdc.identifier.citationExperimental Brain Research, Volumen 202, Issue 1, 2018, Pages 1-14
Identificadordc.identifier.issn00144819
Identificadordc.identifier.other10.1007/s00221-009-2103-z
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/164977
Resumendc.description.abstractThere is no established treatment for the long-term effects produced by perinatal asphyxia. Thus, we investigated the neuroprotection provided by nicotinamide against the effects elicited by perinatal asphyxia on hippocampus and behaviour observed at 30-90 days of age. Asphyxia was induced by immersing foetuses-containing uterine horns, removed from ready-to-deliver rats into a water bath at 37°C for 20 min. Caesarean-delivered siblings were used as controls. Saline or nicotinamide (0.8 mmol/kg, i.p.) was administered to control and asphyxia-exposed animals 24, 48, and 72 h after birth. The animals were examined for morphological changes in hippocampus, focusing on delayed cell death and mossy fibre sprouting, and behaviour, focusing on cognitive behaviour and anxiety. At the age of 30-45 days, asphyxia-exposed rats displayed (1) increased apoptosis, assessed in whole hippocampus by nuclear Hoechst staining, and (2) increased mossy fibre sprouting, restricted to the stratum oriens of d
Idiomadc.language.isoen
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourceExperimental Brain Research
Palabras clavesdc.subjectBehaviour
Palabras clavesdc.subjectHippocampus
Palabras clavesdc.subjectMossy fibres sprouting
Palabras clavesdc.subjectNeonatal-hypoxia
Palabras clavesdc.subjectNiacinamide
Palabras clavesdc.subjectPoly(ADP-ribose) polymerase
Palabras clavesdc.subjectRat
Títulodc.titleNicotinamide prevents the long-term effects of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats
Tipo de documentodc.typeArtículo de revista
Catalogadoruchile.catalogadorSCOPUS
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Descargar archivo

Icon

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivs 3.0 Chile
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivs 3.0 Chile