Parent-of-origin effects for MSX1 in a Chilean population with nonsyndromic cleft lip/palate
Author
dc.contributor.author
Suazo, José
Author
dc.contributor.author
Santos, José Luis
Author
dc.contributor.author
Jara, Lilian
Author
dc.contributor.author
Blanco, Rafael
Admission date
dc.date.accessioned
2019-03-11T13:00:08Z
Available date
dc.date.available
2019-03-11T13:00:08Z
Publication date
dc.date.issued
2010
Cita de ítem
dc.identifier.citation
American Journal of Medical Genetics, Part A, Volumen 152, Issue 8, 2018, Pages 2011-2016
Identifier
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15524825
Identifier
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15524833
Identifier
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10.1002/ajmg.a.33528
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/165043
Abstract
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Based on association and sequencing studies, investigators have postulated muscle segment homeobox 1 (MSX1) as a strong candidate gene involved in the causation of nonsyndromic cleft lip with or without cleft palate (NSCLP). Parent-of-origin effects have been suggested for some NSCLP candidate genes but not for MSX1. The aims of the present study were to test for allele/haplotype associations applying the transmission disequilibrium test (TDT) and the transmission asymmetry test (TAT) to evaluate the possible parent-of-origin effects of MSX1 in Chilean patients with NSCLP. We analyzed five SNPs (rs6446693/c.-425G>T/c.-35G>A/rs3775261/rs12532) located from 6.3 kb upstream to 3′ UTR in a sample of 150 unrelated NSCLP case-parent trios. Four haplotypes showed overtransmission from parents to affected progeny, but individual SNPs did not. Two haplotypes presented allele combination C-G-A-G (P=0.035) and two T-G-C-A (P=0.044) (SNP order rs6446693/c.-35G>A/rs3775261/ rs12532). The rs12532 A