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Authordc.contributor.authorZúñiga, Jessica 
Authordc.contributor.authorVenegas, Francisca 
Authordc.contributor.authorVillarreal, Marcela 
Authordc.contributor.authorNúñez, Daniel 
Authordc.contributor.authorChandía, Marlene 
Authordc.contributor.authorValenzuela, Rodrigo 
Authordc.contributor.authorTapia Opazo, Gladys 
Authordc.contributor.authorVarela, Patricia 
Authordc.contributor.authorVidela Cabrera, Luis 
Authordc.contributor.authorFernández Arancibia, Virginia 
Admission datedc.date.accessioned2019-03-11T13:00:13Z
Available datedc.date.available2019-03-11T13:00:13Z
Publication datedc.date.issued2010
Cita de ítemdc.identifier.citationFree Radical Research, Volumen 44, Issue 8, 2018, Pages 854-863
Identifierdc.identifier.issn10715762
Identifierdc.identifier.issn10292470
Identifierdc.identifier.other10.3109/10715762.2010.485995
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/165068
Abstractdc.description.abstractN-3 polyunsaturated fatty acids (n-3 PUFA) affect inflammatory processes. This study evaluated the effects of dietary supplementation with fish oil on hepatic ischemia-reperfusion (IR) injury in the rat. Parameters of liver injury (serum transaminases and histology) and oxidative stress (serum 8-isoprostanes and hepatic GSH and GSSG), were correlated with NF-κB DNA binding and FA composition and inflammatory cytokine release. N-3 PUFA supplementation significantly increased liver n-3 PUFA content and decreased n-6/n-3 PUFA ratios. IR significantly modified liver histology and enhanced serum transaminases, 8-isoprotanes and inflammatory cytokines, with net reduction in liver GSH levels and net increment in those of GSSG. Early increase (3 h) and late reduction (20 h) in NF-κB activity was induced. All IR-induced changes were normalized by n-3 PUFA supplementation. In conclusion, prevention of liver IR-injury was achieved by n-3 PUFA supplementation, with suppression of oxidative stress
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceFree Radical Research
Keywordsdc.subjectIschemia-reperfusion injury
Keywordsdc.subjectliver preconditioning
Keywordsdc.subjectn-3 polyunsaturated fatty acid
Keywordsdc.subjectNF-κB activation
Keywordsdc.subjectoxidative stress
Keywordsdc.subjectpro-infl ammatory cytokines
Títulodc.titleProtection against in vivo liver ischemia-reperfusion injury by n-3 long-chain polyunsaturated fatty acids in the rat
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile