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Authordc.contributor.authorZúñiga, Jessica 
Authordc.contributor.authorVenegas, Francisca 
Authordc.contributor.authorVillarreal, Marcela 
Authordc.contributor.authorNúñez, Daniel 
Authordc.contributor.authorChandía, Marlene 
Authordc.contributor.authorValenzuela, Rodrigo 
Authordc.contributor.authorTapia Opazo, Gladys 
Authordc.contributor.authorVarela, Patricia 
Authordc.contributor.authorVidela Cabrera, Luis 
Authordc.contributor.authorFernández Arancibia, Virginia 
Cita de ítemdc.identifier.citationFree Radical Research, Volumen 44, Issue 8, 2018, Pages 854-863
Abstractdc.description.abstractN-3 polyunsaturated fatty acids (n-3 PUFA) affect inflammatory processes. This study evaluated the effects of dietary supplementation with fish oil on hepatic ischemia-reperfusion (IR) injury in the rat. Parameters of liver injury (serum transaminases and histology) and oxidative stress (serum 8-isoprostanes and hepatic GSH and GSSG), were correlated with NF-κB DNA binding and FA composition and inflammatory cytokine release. N-3 PUFA supplementation significantly increased liver n-3 PUFA content and decreased n-6/n-3 PUFA ratios. IR significantly modified liver histology and enhanced serum transaminases, 8-isoprotanes and inflammatory cytokines, with net reduction in liver GSH levels and net increment in those of GSSG. Early increase (3 h) and late reduction (20 h) in NF-κB activity was induced. All IR-induced changes were normalized by n-3 PUFA supplementation. In conclusion, prevention of liver IR-injury was achieved by n-3 PUFA supplementation, with suppression of oxidative stress
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceFree Radical Research
Keywordsdc.subjectIschemia-reperfusion injury
Keywordsdc.subjectliver preconditioning
Keywordsdc.subjectn-3 polyunsaturated fatty acid
Keywordsdc.subjectNF-κB activation
Keywordsdc.subjectoxidative stress
Keywordsdc.subjectpro-infl ammatory cytokines
Títulodc.titleProtection against in vivo liver ischemia-reperfusion injury by n-3 long-chain polyunsaturated fatty acids in the rat
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile