Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis
Author
dc.contributor.author
González Ramos, Reinaldo
Author
dc.contributor.author
Van Langendonckt, Anne
Author
dc.contributor.author
Defrre, Sylvie
Author
dc.contributor.author
Lousse, Jean Christophe
Author
dc.contributor.author
Colette, Sebastien
Author
dc.contributor.author
Devoto, Luigi
Author
dc.contributor.author
Donnez, Jacques
Admission date
dc.date.accessioned
2019-03-11T13:00:22Z
Available date
dc.date.available
2019-03-11T13:00:22Z
Publication date
dc.date.issued
2010
Cita de ítem
dc.identifier.citation
Fertility and Sterility, Volumen 94, Issue 6, 2018, Pages 1985-1994
Identifier
dc.identifier.issn
00150282
Identifier
dc.identifier.other
10.1016/j.fertnstert.2010.01.013
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/165104
Abstract
dc.description.abstract
Objective: To evaluate the role of nuclear factor-κB (NF-κB) in the pathogenesis of endometriosis. Design: A literature search was conducted in PubMed to identify all relevant citations. Result(s): Our findings highlight the important role of NF-κB in the pathophysiology of endometriosis. In vitro and in vivo studies show that NF-κB-mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells. Constitutive activation of NF-κB has been demonstrated in endometriotic lesions and peritoneal macrophages of endometriosis patients. Agents blocking NF-κB are effective inhibitors of endometriosis development and some drugs with known NF-κB inhibitory properties have proved efficient at reducing endometriosis-associated symptoms in women. Iron overload activates NF-κB in macrophages. NF-κB activation in macrophages and ectopic endometrial cells stimulates synthesis of proinflammatory cytokines, generating a positi