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Authordc.contributor.authorArmisen Yáñez, Ricardo 
Authordc.contributor.authorMarcelain Cubillos, Katherine 
Authordc.contributor.authorSimon, Felipe 
Authordc.contributor.authorTapia, Julio C. 
Authordc.contributor.authorToro, Jessica 
Authordc.contributor.authorQuest, Andrew F. G. 
Authordc.contributor.authorStutzin Schottlander, Andrés 
Cita de ítemdc.identifier.citationJournal of Cellular Physiology, Volumen 226, Issue 1, 2018, Pages 103-109
Abstractdc.description.abstractAltered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin lymphoma, prostate, and cervical cancer. However, whether such changes in TRPM4 expression may be relevant to genesis or progression of cancer remains unknown. Here we show that reducing TRPM4 expression decreases proliferation of HeLa cells, a cervical cancer-derived cell line. In this cell line, constitutive TRPM4 silencing promoted GSK-3β-dependent degradation of β-catenin and reduced β-catenin/Tcf/Lef-dependent transcription. Conversely, overexpression of TRPM4 in T-REx 293 cells (a HEK293-derived cell line) increased cell proliferation and β-catenin levels. Our results identify TRPM4 as an important, unanticipated regulator of the β-catenin pathway, where aberrant signaling is frequently associated with cancer. © 2010 Wiley-Liss, Inc.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceJournal of Cellular Physiology
Keywordsdc.subjectMedicine (all)
Keywordsdc.subjectClinical Biochemistry
Keywordsdc.subjectCell Biology
Títulodc.titleTRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile