Seroepidemiological study of Pneumocystis jirovecii infection in healthy infants in Chile using recombinant fragments of the P. jirovecii major surface glycoprotein
Author
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Djawe, Kpandja
Author
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Daly, Kieran R.
Author
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Vargas, Sergio L.
Author
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Santolaya de Pablo, María Elena
Author
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Ponce, Carolina A.
Author
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Bustamante, Rebeca
Author
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Koch, Judith
Author
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Levin, Linda
Author
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Walzer, Peter D.
Admission date
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2019-03-11T13:00:43Z
Available date
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2019-03-11T13:00:43Z
Publication date
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2010
Cita de ítem
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International Journal of Infectious Diseases, Volumen 14, Issue 12, 2018,
Identifier
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12019712
Identifier
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10.1016/j.ijid.2010.07.003
Identifier
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https://repositorio.uchile.cl/handle/2250/165126
Abstract
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Objectives: To characterize the seroepidemiological features of Pneumocystis jirovecii infection in healthy Chilean children using overlapping fragments (A, B, C) of the P. jirovecii major surface glycoprotein (Msg). Methods: Serum antibodies to MsgA, MsgB, and MsgC were measured every 2 months by enzyme-linked immunosorbent assay (ELISA) in 45 Chilean infants from about age 2 months to 2 years. Results: Peak antibody levels (usually reached at age 6 months) and the force (or rate) of infection were somewhat greater for MsgC than for MsgA. Significant seasonal variation in antibody levels was only found with MsgA. Respiratory infections occurred in most children, but nasopharyngeal aspirates were of limited value in detecting the organism. In contrast, serological responses commonly occurred, and higher levels only to MsgC were significantly related to the number of infections. Conclusions: Serological responses to recombinant Msg fragments provide new insights into the epidemiological
Seroepidemiological study of Pneumocystis jirovecii infection in healthy infants in Chile using recombinant fragments of the P. jirovecii major surface glycoprotein