Validity of the NIHSS in predicting arterial occlusion in cerebral infarction is time-dependent
Author
dc.contributor.author
Olavarría, V. V.
Author
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Delgado, I.
Author
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Hoppe, A.
Author
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Brunser,
Author
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Cárcamo, D.
Author
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Díaz-Tapia, V.
Author
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Lavados Germain, Pablo Manuel
Admission date
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2019-03-11T13:00:54Z
Available date
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2019-03-11T13:00:54Z
Publication date
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2011
Cita de ítem
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Neurology, Volumen 76, Issue 1, 2018, Pages 62-68
Identifier
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1526632X
Identifier
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00283878
Identifier
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10.1212/WNL.0b013e318203e977
Identifier
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https://repositorio.uchile.cl/handle/2250/165165
Abstract
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Background: The NIH Stroke Scale (NIHSS) is used to assess acute ischemic stroke severity and outcome. High NIHSS scores are usually associated with arterial occlusion but it is unknown what the effect of time to clinical evaluation (TTCE) in this association is. We tested the NIHSS scores as an instrument to determine vessel occlusion (VO) at different time points from symptom onset. Methods: Patients were selected from our prospective stroke database if they had admission NIHSS scores and intracranial vessel neuroimaging studies. We dichotomized patients according to VO and TTCE. Receiver operating curves, c statistics, and odds ratios were calculated to study the validity of the NIHSS score. Results: Among 463 patients (mean age 70.2 years, 53.1% male, median NIHSS 4, median TTCE 3.3 hours), 22.5% had arterial occlusion. Median NIHSS scores were higher in patients with VO, 10.5 (interquartile range 5-18) vs 3 (2-7), p < 0.001, and in those with TTCE <6 hours, 15 (interquartile range