Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino
Author
dc.contributor.author
López M., Jaime
Author
dc.contributor.author
Ili, Carmen G.
Author
dc.contributor.author
Brebi, Priscilla
Author
dc.contributor.author
García M., Patricia
Author
dc.contributor.author
Capurro V., Italo
Author
dc.contributor.author
Guzmán G., Pablo
Author
dc.contributor.author
Suárez P., Eugenio
Author
dc.contributor.author
Ojeda F., José Manuel
Author
dc.contributor.author
Roa S., Juan Carlos
Admission date
dc.date.accessioned
2019-03-11T13:00:54Z
Available date
dc.date.available
2019-03-11T13:00:54Z
Publication date
dc.date.issued
2010
Cita de ítem
dc.identifier.citation
Revista Medica de Chile, Volumen 138, Issue 11, 2018, Pages 1343-1350
Identifier
dc.identifier.issn
07176163
Identifier
dc.identifier.issn
00349887
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/165169
Abstract
dc.description.abstract
Background: The relationship between human papillomavirus (HPV) and uterine cervical cancer (UCC) is widely known and accepted. Aim: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. Material and Methods: Using a combination of PCR and Reverse Line Blot technique, 235 formalin fixed paraffin embedded samples, with diagnosis of low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL) were genotyped. Results: HPV was detected in 61.2% of LSIL and 78.1% of HSIL. The main genotypes found were HPV 16, 18, 31, 45, 56 y 58. HPV 16 was the most common in both LSIL (18.1%) and HSIL (36.9%). HPV 16 or 18 were present in 25.1% and 47.1% of the LSIL and HSIL respectively. In both LSIL and HSIL, the predominant viral genotypes were those types classified as with a high oncogenic risk. Conclusions: HPV genotypes 16, 18, 31, 45, 56 y 58 were the most common in our series. HPV 16 and 18, viral types
Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino