Reintubation and risk of morbidity and mortality in preterm infants after surfactant replacement therapy
Author | dc.contributor.author | Guardia, C. G. | |
Author | dc.contributor.author | Moya, F. R. | |
Author | dc.contributor.author | Sinha, S. | |
Author | dc.contributor.author | Gadzinowski, J. | |
Author | dc.contributor.author | Donn, S. M. | |
Author | dc.contributor.author | Simmons, P. | |
Author | dc.contributor.author | Segal, R. | |
Admission date | dc.date.accessioned | 2019-03-11T13:01:44Z | |
Available date | dc.date.available | 2019-03-11T13:01:44Z | |
Publication date | dc.date.issued | 2011 | |
Cita de ítem | dc.identifier.citation | Journal of Neonatal-Perinatal Medicine, Volumen 4, Issue 2, 2018, Pages 101-109 | |
Identifier | dc.identifier.issn | 19345798 | |
Identifier | dc.identifier.issn | 18784429 | |
Identifier | dc.identifier.other | 10.3233/NPM-2011-2736 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/165262 | |
Abstract | dc.description.abstract | Background: In preterm infants at risk for RDS, reintubation following surfactant replacement therapy and successful extubation may be associated with poor clinical outcomes. Methods: Initial extubation, reintubation, mortality, and major morbidity rates associated with prematurity from two surfactant trials utilizing lucinactant, colfosceril palmitate, beractant, and poractant alfa were compared for reintubated infants versus infants who were not reintubated, and among treatment groups. Results: Initial extubation rates were similar among surfactant treatments in both trials (80-84%; p = ns). Reintubated infants had significantly higher mortality rates versus infants who were successfully extubated and never reintubated (18% vs. 0.5% respectively; OR 42 [CI 15.1-114]). Reintubated infants also had higher rates of BPD (OR 8.2; CI 5.8-11.5), air leak (3.0; 2.1-4.5), sepsis (3.6; 2.6-4.9), NEC (2.6; 1.8-3.7), IVH (3.3; 2.4-4.5), and PVL (1.8; 1.1-2.8). Reintubation rates were lower (p < | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Journal of Neonatal-Perinatal Medicine | |
Keywords | dc.subject | lucinactant | |
Keywords | dc.subject | mortality | |
Keywords | dc.subject | reintubation | |
Keywords | dc.subject | Respiratory distress syndrome | |
Keywords | dc.subject | surfactant | |
Título | dc.title | Reintubation and risk of morbidity and mortality in preterm infants after surfactant replacement therapy | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI |
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