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Authordc.contributor.authorSánchez, Gina 
Authordc.contributor.authorFernández, Carolina 
Authordc.contributor.authorMontecinos, Luis 
Authordc.contributor.authorDomenech Lira, Raúl 
Authordc.contributor.authorDonoso Laurent, Paulina 
Admission datedc.date.accessioned2019-03-11T13:01:49Z
Available datedc.date.available2019-03-11T13:01:49Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationBiochemical and Biophysical Research Communications, Volumen 410, Issue 4, 2018, Pages 916-921
Identifierdc.identifier.issn0006291X
Identifierdc.identifier.issn10902104
Identifierdc.identifier.other10.1016/j.bbrc.2011.06.095
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165280
Abstractdc.description.abstractCardioprotection by preconditioning is a central issue of current research on heart function. Several reports indicate that preventing the assembly and opening of the mitochondrial permeability transition pore (mPTP) protects the heart against ischemia-reperfusion injury. We have previously reported that brief episodes of tachycardia decrease the infarct size produced by subsequent prolonged occlusion of a coronary artery, indicating that controlled tachycardia is an effective preconditioning manoeuvre. The effects of preconditioning tachycardia on mPTP activity have not been reported. Therefore, in this work we investigated if preconditioning tachycardia protects against calcium-induced mitochondrial swelling, a measure of mPTP activity. We found that tachycardia decreased by 2.5-fold the rate of mitochondrial calcium-induced swelling, a factor that presumably contributes to the cardioprotective effects of tachycardia. The oxidative status of the cell increased after tachycardia, as e
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBiochemical and Biophysical Research Communications
Keywordsdc.subjectCardioprotection
Keywordsdc.subjectCyclophilin-D
Keywordsdc.subjectMitochondrial swelling
Keywordsdc.subjectPreconditioning
Keywordsdc.subjectProtein redox modification
Keywordsdc.subjectS-glutathionylation
Títulodc.titlePreconditioning tachycardia decreases the activity of the mitochondrial permeability transition pore in the dog heart
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile