Ovarian function in adolescents with McCune-Albright syndrome
Author
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Sotomayor, Karina
Author
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Iñíguez Vila, Germán
Author
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Ugarte, Francisca
Author
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Villarroel, Claudio
Author
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López, Patricia
Author
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Avila, Alejandra
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Codner Dujovne, Ethel
Author
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Cassorla Goluboff, Fernando
Admission date
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2019-03-11T13:02:19Z
Available date
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2019-03-11T13:02:19Z
Publication date
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2011
Cita de ítem
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Journal of Pediatric Endocrinology and Metabolism, Volumen 24, Issue 7-8, 2018, Pages 525-528
Identifier
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0334018X
Identifier
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21910251
Identifier
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10.1515/JPEM.2011.265
Identifier
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https://repositorio.uchile.cl/handle/2250/165314
Abstract
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Objective: To evaluate ovarian function, especially ovulation rate, in adolescents with McCune-Albright syndrome (MAS) and a history of peripheral precocious puberty. Design: Prospective cross-sectional study. Setting: Academic center. Patient(s): A total of eight adolescents with MAS were compared with 15 healthy adolescents matched by age, Tanner stage and body mass index. Intervention(s): We determined basal gonadotropins, sex steroids, sex hormone binding globulin, anti-Müllerian hormone, glucose and insulin. A leuprolide acetate test was performed to measure luteinizing hormone (LH) and follicle stimulating hormone (FSH) (at 0 and 3 h), and 17B-estradiol, testosterone and 17-OH-progesterone (at 0 and 24 h). Salivary progesterone levels were used to assess ovulation during the 13th, 18th, 23rd and 28th days of each menstrual cycle for three to five consecutive cycles, and one pelvic ultrasound was performed during the follicular phase. Main outcome measure(s): Ovulation rate in ado