Salmonella bongori provides insights into the evolution of the salmonellae
Author
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Fookes, Maria
Author
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Schroeder, Gunnar N.
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Langridge, Gemma C.
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Blondel, Carlos J.
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Mammina, Caterina
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Connor, Thomas R.
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Seth-Smith, Helena
Author
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Vernikos, Georgios S.
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Robinson, Keith S.
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Sanders, Mandy
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Petty, Nicola K.
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Kingsley, Robert A.
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Bäumler, Andreas J.
Author
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Nuccio, Sean
Admission date
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2019-03-11T13:02:20Z
Available date
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2019-03-11T13:02:20Z
Publication date
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2011
Cita de ítem
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PLoS Pathogens, Volumen 7, Issue 8, 2018,
Identifier
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15537366
Identifier
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15537374
Identifier
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10.1371/journal.ppat.1002191
Identifier
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https://repositorio.uchile.cl/handle/2250/165321
Abstract
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The genus Salmonella contains two species, S. bongori and S. enterica. Compared to the well-studied S. enterica there is a marked lack of information regarding the genetic makeup and diversity of S. bongori. S. bongori has been found predominantly associated with cold-blooded animals, but it can infect humans. To define the phylogeny of this species, and compare it to S. enterica, we have sequenced 28 isolates representing most of the known diversity of S. bongori. This cross-species analysis allowed us to confidently differentiate ancestral functions from those acquired following speciation, which include both metabolic and virulence-associated capacities. We show that, although S. bongori inherited a basic set of Salmonella common virulence functions, it has subsequently elaborated on this in a different direction to S. enterica. It is an established feature of S. enterica evolution that the acquisition of the type III secretion systems (T3SS-1 and T3SS-2) has been followed by the se