Calcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams in nonpregnant women
Author
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Gaitán, Diego
Author
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Flores, Sebastián
Author
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Saavedra, Pía
Author
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Miranda, Constanza
Author
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Olivares, Manuel
Author
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Arredondo, Miguel
Author
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López de Romaña, Daniel
Author
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Lönnerdal, Bo
Author
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Pizarro Aguirre, Fernando
Admission date
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2019-03-11T13:02:21Z
Available date
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2019-03-11T13:02:21Z
Publication date
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2011
Cita de ítem
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Journal of Nutrition, Volumen 141, Issue 9, 2018, Pages 1652-1656
Identifier
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00223166
Identifier
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15416100
Identifier
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10.3945/jn.111.138651
Identifier
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https://repositorio.uchile.cl/handle/2250/165327
Abstract
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Calcium is the only known component in the diet that may affect absorption of both nonheme and heme iron. However, the evidence for a calcium effect on iron absorption mainly comes from studies that did not isolate the effect of calcium from that of other dietary components, because it was detected in single-meal studies. Our objective was to establish potential effects of calcium on absorption of nonheme and heme iron and the dose response for this effect in the absence of a meal. Fifty-four healthy, nonpregnant women were selected to participate in 4 iron absorption studies using iron radioactive tracers. We evaluated the effects of calcium doses between 200 and 1500 mg on absorption of 5 mg nonheme iron (as ferrous sulfate). We also evaluated the effects of calcium doses between 200 and 800 mg on absorption of 5 mg heme iron [as concentrated RBC (CRBC)]. Calcium was administered as calcium chloride in all studies and minerals were ingested on an empty stomach. Calcium doses ≥ 1000 m