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Authordc.contributor.authorGabrielli, Luigi 
Authordc.contributor.authorCastro, Pablo F. 
Authordc.contributor.authorGodoy, Ivan 
Authordc.contributor.authorMellado, Rosemarie 
Authordc.contributor.authorBourge, Robert C. 
Authordc.contributor.authorAlcaíno Gálvez, Hernán Alejandro 
Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorGreig, Douglas 
Authordc.contributor.authorVerdejo, Hugo 
Authordc.contributor.authorNavarro, Mario 
Authordc.contributor.authorLopez, Rafael 
Authordc.contributor.authorToro, Barbra 
Authordc.contributor.authorQuiroga, Clara 
Authordc.contributor.authorDíaz Araya, Guillermo 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorGarcia, Lo 
Cita de ítemdc.identifier.citationJournal of Cardiac Failure, Volumen 17, Issue 12, 2018, Pages 1012-1017
Abstractdc.description.abstractBackground: Systemic endothelial dysfunction and increased oxidative stress have been observed in pulmonary arterial hypertension (PAH). We evaluate whether oxidative stress and endothelial dysfunction are associated with acute pulmonary vascular bed response to an inhaled prostanoid in PAH patients. Methods: Fourteen idiopathic PAH patients and 14 controls were included. Oxidative stress was assessed through plasma malondialdehyde (MDA) levels and xanthine oxidase (XO) and endothelial-bound superoxide dismutase (eSOD) activity. Brachial artery endothelial-dependent flow-mediated vasodilation (FMD) was used to evaluate endothelial function. Hemodynamic response to inhaled iloprost was assessed with transthoracic echocardiography. Results: PAH patients showed impaired FMD (2.8 ± 0.6 vs. 10.7 ± 0.6%, P <.01), increased MDA levels and XO activity (0.6 ± 0.2 vs. 0.3 ± 0.2 μM, P <.01 and 0.04 ± 0.01 vs. 0.03 ± 0.01 U/mL, P =.02, respectively) and decreased eSOD activity (235 ± 23 vs. 461 ±
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceJournal of Cardiac Failure
Keywordsdc.subjectendothelial function
Keywordsdc.subjectendothelial superoxide dismutase
Keywordsdc.subjectoxidative stress
Keywordsdc.subjectPulmonary hypertension
Títulodc.titleSystemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular response to inhaled prostanoid in pulmonary artery hypertension patients
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile