Itraconazole 800 mg for the prophylaxis of fungal infections in patients with acute leukemia and severe neutropenia Resultados de profilaxis con itraconazol 800 mg/día vía oral en adultos con leucemia aguda y neutropenia de alto riesgo. hospital del salva
Author
dc.contributor.author
Andrade, Alejandro M.
Author
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Puga, Barbara L.
Author
dc.contributor.author
Guerra, Carolina C.
Author
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Molina, Javiera E.
Author
dc.contributor.author
Capurro, Marisa C.
Admission date
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2019-03-11T13:03:06Z
Available date
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2019-03-11T13:03:06Z
Publication date
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2011
Cita de ítem
dc.identifier.citation
Revista Medica de Chile, Volumen 139, Issue 9, 2018, Pages 1128-1134
Identifier
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00349887
Identifier
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07176163
Identifier
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10.4067/S0034-98872011000900003
Identifier
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https://repositorio.uchile.cl/handle/2250/165464
Abstract
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Background: Systemic fungal infections and specifically invasive aspergillosis (IA) are associated with a high morbi-mortality rate in patients with hematologic malignancies. Itraconazole kinetic studies show that plasma levels are not satisfactory, even though there is a reduction of the severity in clinical cases. Aim: To evaluate the results of oral prophylaxis with high dose itraconazole, 400 mg bid, among patients with adult acute leukemia. Material and Methods: Prospective analysis of 93 high risk febrile episodes (with an absolute neutrophil count of less than 500 x mm3 for more 10 days), that occurred in 76 patients. Results: Seventy five percent of episodes occurred in patients with acute myeloid leukemia and 25% in patients with acute lymphoblastic leukemia. Fifty two percent occurred during the induction of chemotherapy. Median duration of severe neutropenia was 21 days (range 10-48). Median duration of itraconazole prophylaxis was 17 days (range 6-34). A low frequency of in
Itraconazole 800 mg for the prophylaxis of fungal infections in patients with acute leukemia and severe neutropenia Resultados de profilaxis con itraconazol 800 mg/día vía oral en adultos con leucemia aguda y neutropenia de alto riesgo. hospital del salva