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Authordc.contributor.authorAyala, Pedro 
Authordc.contributor.authorMontenegro, José 
Authordc.contributor.authorVivar, Raúl 
Authordc.contributor.authorLetelier, Alan 
Authordc.contributor.authorUrroz, Pablo Aránguiz 
Authordc.contributor.authorCopaja, Miguel 
Authordc.contributor.authorPivet, Deisy 
Authordc.contributor.authorHumeres, Claudio 
Authordc.contributor.authorTroncoso, Rodrigo 
Authordc.contributor.authorVicencio, José Miguel 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorDíaz Araya, Guillermo 
Admission datedc.date.accessioned2019-03-11T13:03:08Z
Available datedc.date.available2019-03-11T13:03:08Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationExperimental and Molecular Pathology, Volumen 92, Issue 1, 2018, Pages 97-104
Identifierdc.identifier.issn00144800
Identifierdc.identifier.issn10960945
Identifierdc.identifier.other10.1016/j.yexmp.2011.10.012
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165479
Abstractdc.description.abstractIncreasing evidence indicates that endoplasmic reticulum (ER) stress is involved in various diseases. In the human heart, ischemia/reperfusion has been correlated to ER stress, and several markers of the unfolded protein response (UPR) participate during cardiac remodeling and fibrosis. Here, we used isoproterenol (ISO) injection as a model for in vivo cardiac fibrosis. ISO induced significant cardiomyocyte loss and collagen deposition in the damaged areas of the endocardium. These responses were accompanied by an increase in the protein levels of the luminal ER chaperones BIP and PDI, as well as an increase in the UPR effector CHOP. The use of the chemical chaperone 4-phenylbutyric acid (4-PBA) prevented the activation of the UPR, the increase in luminal chaperones and also, leads to decreased collagen deposition, cardiomyocyte loss into the damaged zones. Our results suggest that cardiac damage and fibrosis induced in vivo by the beta-adrenergic agonist ISO are tightly related to ER
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceExperimental and Molecular Pathology
Keywordsdc.subject4-Phenylbutyric acid
Keywordsdc.subjectEndoplasmic reticulum stress
Keywordsdc.subjectFibrosis
Keywordsdc.subjectHeart
Keywordsdc.subjectIsoproterenol
Títulodc.titleAttenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile