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Authordc.contributor.authorSebollela, Adriano 
Authordc.contributor.authorFreitas-Correa, Leo 
Authordc.contributor.authorOliveira, Fabio F. 
Authordc.contributor.authorPaula-Lima, Andrea C. 
Authordc.contributor.authorSaraiva, Leonardo M. 
Authordc.contributor.authorMartins, Samantha M. 
Authordc.contributor.authorMota, Louise D. 
Authordc.contributor.authorTorres, Cesar 
Authordc.contributor.authorAlves-Leon, Soniza 
Authordc.contributor.authorDe Souza, Jorge M. 
Authordc.contributor.authorCarraro, Dirce María 
Authordc.contributor.authorBrentani, Helena 
Authordc.contributor.authorDe Felice, Fernanda G. 
Authordc.contributor.authorFerreir 
Admission datedc.date.accessioned2019-03-11T13:03:08Z
Available datedc.date.available2019-03-11T13:03:08Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationJournal of Biological Chemistry, Volumen 287, Issue 10, 2018, Pages 7436-7445
Identifierdc.identifier.issn00219258
Identifierdc.identifier.issn1083351X
Identifierdc.identifier.other10.1074/jbc.M111.298471
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/165481
Abstractdc.description.abstractCognitive decline in Alzheimer disease (AD) is increasingly attributed to the neuronal impact of soluble oligomers of the amyloid-β peptide (AβOs). Current knowledge on the molecular and cellular mechanisms underlying the toxicity of AβOs stems largely from rodent-derived cell/tissue culture experiments or from transgenic models of AD, which do not necessarily recapitulate the complexity of the human disease. Here, we used DNA microarray and RT-PCR to investigate changes in transcription in adult human cortical slices exposed to sublethal doses of AβOs. The results revealed a set of 27 genes that showed consistent differential expression upon exposure of slices from three different donors to AβOs. Functional classification of differentially expressed genes revealed that AβOs impact pathways important for neuronal physiology and known to be dysregulated in AD, including vesicle trafficking, cell adhesion, actin cytoskeleton dynamics, and insulin signaling. Most genes (70%) were down-reg
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Biological Chemistry
Keywordsdc.subjectBiochemistry
Keywordsdc.subjectMolecular Biology
Keywordsdc.subjectCell Biology
Títulodc.titleAmyloid-β oligomers induce differential gene expression in adult human brain slices
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile