Protective effect of melatonin on damage in the sperm parameters of mice exposed to diazinon Efecto protector de la melatonina sobre el daño en los parámetros espermáticos de ratones expuestos a diazinón
Author
dc.contributor.author
Sarabia, L.
Author
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Espinoza-Navarro, O.
Author
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Maurer, I.
Author
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Ponce, C.
Author
dc.contributor.author
Bustos-Obregón, E.
Admission date
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2019-03-11T13:03:12Z
Available date
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2019-03-11T13:03:12Z
Publication date
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2011
Cita de ítem
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International Journal of Morphology, Volumen 29, Issue 4, 2018, Pages 1241-1247
Identifier
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07179502
Identifier
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07179367
Identifier
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10.4067/S0717-95022011000400029
Identifier
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https://repositorio.uchile.cl/handle/2250/165501
Abstract
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Since normal sperm parameters can be altered by organophosphorous pesticides, this study intended to determine if melatonin is able to prevent the damage on sperm quality after an acute exposure to diazinon. Adult male mice were injected intraperitoneally with melatonin, diazinon (1/3 or 2/3 LD50) or both, and sperm parameters were evaluated on days 1 or 32 post injection. Groups treated with diazinon showed elevated lipid peroxidation levels on day 1 post treatment, while groups pretreated with melatonin before diazinon showed no difference compared to control. Sperm count showed a significant decrease in both diazinontreated groups only on day 32 post injection; no differences were observed in groups pretreated with melatonin prior to diazinon compared to control. The percentage of abnormal sperm morphology increased in the diazinon-treated groups only on day 32 postinjection. The administration of melatonin prior to exposure to diazinon prevents the alteration of sperm parameters co
Protective effect of melatonin on damage in the sperm parameters of mice exposed to diazinon Efecto protector de la melatonina sobre el daño en los parámetros espermáticos de ratones expuestos a diazinón