Evolutionary plasticity of habenular asymmetry with a conserved efferent connectivity pattern
Author
dc.contributor.author
Villalón, Aldo
Author
dc.contributor.author
Sepulveda, Mauricio
Author
dc.contributor.author
Guerrero, Néstor
Author
dc.contributor.author
Meynard, Margarita M.
Author
dc.contributor.author
Palma, Karina
Author
dc.contributor.author
Concha, Miguel L.
Admission date
dc.date.accessioned
2019-03-11T13:03:48Z
Available date
dc.date.available
2019-03-11T13:03:48Z
Publication date
dc.date.issued
2012
Cita de ítem
dc.identifier.citation
PLoS ONE, Volumen 7, Issue 4, 2018,
Identifier
dc.identifier.issn
19326203
Identifier
dc.identifier.other
10.1371/journal.pone.0035329
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/165512
Abstract
dc.description.abstract
The vertebrate habenulae (Hb) is an evolutionary conserved dorsal diencephalic nuclear complex that relays information from limbic and striatal forebrain regions to the ventral midbrain. One key feature of this bilateral nucleus is the presence of left-right differences in size, cytoarchitecture, connectivity, neurochemistry and/or gene expression. In teleosts, habenular asymmetry has been associated with preferential innervation of left-right habenular efferents into dorso-ventral domains of the midbrain interpeduncular nucleus (IPN). However, the degree of conservation of this trait and its relation to the structural asymmetries of the Hb are currently unknown. To address these questions, we performed the first systematic comparative analysis of structural and connectional asymmetries of the Hb in teleosts. We found striking inter-species variability in the overall shape and cytoarchitecture of the Hb, and in the frequency, strength and to a lesser degree, laterality of habenular vol