Assesment of arterial damage by noninvasive peripheral arterial tonometry in non-diabetic hemodialysis patients Daño arterial asociado a la enfermedad renal crónica: Evaluación mediante técnicas de laboratorio no invasivo en pacientes hemodializados

Abstract

Background: Hemodialysis patients (HD) display high rates of cardiac disease and mortality. The cardiovascular morbidity and mortality of HD patients is attributable in a signifi cant proportion to endothelial dysfunction, arterial stiffness, and vascular calcifi cations. Aim: To measure vascular reactivity in HD subjects and compare them with healthy volunteers. Material and Methods: Forty eight non diabetic patients aged 58 ± 4.6 years (29 males) on hemodialysis for a mean lapse of 4.8 years were studied. Arterial stiffness was measured in the radial artery. Pulse wave velocity was measured by noninvasive peripheral arterial tonometry in carotid and femoral arteries. Endothelial function was assessed, measuring reactive hyperemia response after a 5 min period of ischemia. As a control, all values were also measured in age and gender-matched healthy volunteers. Results: Arterial stiffness was signifi cantly higher in HD patients than controls (23.9 ± 3.3 and 18.4 ± 3.4% respectively,