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Author | dc.contributor.author | Chiong Lay, Mario | |
Author | dc.contributor.author | Wang, Z. V. | |
Author | dc.contributor.author | Pedrozo Cibils, Zully | |
Author | dc.contributor.author | Cao, D. J. | |
Author | dc.contributor.author | Troncoso, R. | |
Author | dc.contributor.author | Ibacache, M. | |
Author | dc.contributor.author | Criollo, A. | |
Author | dc.contributor.author | Nemchenko, A. | |
Author | dc.contributor.author | Hill, J. A. | |
Author | dc.contributor.author | Lavandero González, Sergio | |
Admission date | dc.date.accessioned | 2019-03-11T13:04:04Z | |
Available date | dc.date.available | 2019-03-11T13:04:04Z | |
Publication date | dc.date.issued | 2011 | |
Cita de ítem | dc.identifier.citation | Cell Death and Disease, Volumen 2, Issue 12, 2018, | |
Identifier | dc.identifier.issn | 20414889 | |
Identifier | dc.identifier.other | 10.1038/cddis.2011.130 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/165606 | |
Abstract | dc.description.abstract | Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Although treatments have improved, development of novel therapies for patients with CVD remains a major research goal. Apoptosis, necrosis, and autophagy occur in cardiac myocytes, and both gradual and acute cell death are hallmarks of cardiac pathology, including heart failure, myocardial infarction, and ischemia/reperfusion. Pharmacological and genetic inhibition of autophagy, apoptosis, or necrosis diminishes infarct size and improves cardiac function in these disorders. Here, we review recent progress in the fields of autophagy, apoptosis, and necrosis. In addition, we highlight the involvement of these mechanisms in cardiac pathology and discuss potential translational implications. © 2011 Macmillan Publishers Limited. All rights reserved. | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Cell Death and Disease | |
Keywords | dc.subject | Apoptosis | |
Keywords | dc.subject | Autophagy | |
Keywords | dc.subject | Cardiovascular diseases | |
Keywords | dc.subject | Heart | |
Keywords | dc.subject | Necrosis | |
Título | dc.title | Cardiomyocyte death: Mechanisms and translational implications | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile