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Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorWang, Z. V. 
Authordc.contributor.authorPedrozo Cibils, Zully 
Authordc.contributor.authorCao, D. J. 
Authordc.contributor.authorTroncoso, R. 
Authordc.contributor.authorIbacache, M. 
Authordc.contributor.authorCriollo, A. 
Authordc.contributor.authorNemchenko, A. 
Authordc.contributor.authorHill, J. A. 
Authordc.contributor.authorLavandero González, Sergio 
Admission datedc.date.accessioned2019-03-11T13:04:04Z
Available datedc.date.available2019-03-11T13:04:04Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationCell Death and Disease, Volumen 2, Issue 12, 2018,
Identifierdc.identifier.issn20414889
Identifierdc.identifier.other10.1038/cddis.2011.130
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/165606
Abstractdc.description.abstractCardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Although treatments have improved, development of novel therapies for patients with CVD remains a major research goal. Apoptosis, necrosis, and autophagy occur in cardiac myocytes, and both gradual and acute cell death are hallmarks of cardiac pathology, including heart failure, myocardial infarction, and ischemia/reperfusion. Pharmacological and genetic inhibition of autophagy, apoptosis, or necrosis diminishes infarct size and improves cardiac function in these disorders. Here, we review recent progress in the fields of autophagy, apoptosis, and necrosis. In addition, we highlight the involvement of these mechanisms in cardiac pathology and discuss potential translational implications. © 2011 Macmillan Publishers Limited. All rights reserved.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceCell Death and Disease
Keywordsdc.subjectApoptosis
Keywordsdc.subjectAutophagy
Keywordsdc.subjectCardiovascular diseases
Keywordsdc.subjectHeart
Keywordsdc.subjectNecrosis
Títulodc.titleCardiomyocyte death: Mechanisms and translational implications
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile