Show simple item record

Authordc.contributor.authorSandoval Acuña, Cristian 
Authordc.contributor.authorLópez Alarcón, Camilo 
Authordc.contributor.authorAliaga, Margarita E. 
Authordc.contributor.authorSpeisky Cosoy, Hernán 
Admission datedc.date.accessioned2019-03-11T13:04:04Z
Available datedc.date.available2019-03-11T13:04:04Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationChemico-Biological Interactions, Volumen 199, Issue 1, 2018, Pages 18-28
Identifierdc.identifier.issn00092797
Identifierdc.identifier.issn18727786
Identifierdc.identifier.other10.1016/j.cbi.2012.05.006
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/165607
Abstractdc.description.abstractMitochondrial dysfunction plays a major role in the development of oxidative stress and cytotoxicity induced by non-steroidal anti-inflammatory drugs (NSAIDs). A major objective of the present study was to investigate whether in vitro the NSAIDs, aspirin, indomethacin, diclofenac, piroxicam and ibuprofen, which feature different chemical structures, are able to inhibit mitochondrial complex I. All NSAIDs were effective inhibitors when added both, directly to mitochondria isolated from rat duodenum epithelium (50 μM) or to Caco-2 cells (250 μM). In the former system, complex I inhibition was concentration-dependent and susceptible to competition and reversion by the addition of coenzyme Q (32.5-520 μM). Based on reports suggesting a potential gastro-protective activity of quercetin, the ability of this flavonoid to protect isolated mitochondria against NSAIDs-induced complex I inhibition was evaluated. Low micromolar concentrations of quercetin (1-20 μM) protected against such inhibitio
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceChemico-Biological Interactions
Keywordsdc.subjectComplex I
Keywordsdc.subjectElectron transporting chain
Keywordsdc.subjectMitochondria
Keywordsdc.subjectNSAIDs
Keywordsdc.subjectQuercetin
Keywordsdc.subjectUbiquinone
Títulodc.titleInhibition of mitochondrial complex i by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile