Relation of genetic variants of CYP2A6 with tobacco dependence and smoking habit in Chilean subjects. A pilot study Variantes genéticas de CYP2A6 y su relación con la dependencia tabáquica y el hábito de fumar en una muestra individuos chilenos. Un estudi
Author
dc.contributor.author
Lillo Cáceres, Dante D.
Author
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Alvarado, Sergio A.
Author
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Martínez, Paulina
Author
dc.contributor.author
Quiñones, Luis A.
Admission date
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2019-03-11T13:19:28Z
Available date
dc.date.available
2019-03-11T13:19:28Z
Publication date
dc.date.issued
2012
Cita de ítem
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Revista Medica de Chile, Volumen 140, Issue 4, 2018, Pages 436-441
Identifier
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00349887
Identifier
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07176163
Identifier
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10.4067/S0034-98872012000400003
Identifier
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https://repositorio.uchile.cl/handle/2250/165625
Abstract
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Background: Genetic and metabolic factors associated with nicotine metabolism may be related to smoking behavior. Aim: To assess the prevalence of allelic and genotype variants of CYP2A6 in a sample of Chilean subjects and to evaluate their relationship with smoking and tobacco dependence. Material and Methods: The genotype frequencies for *2, *3 and *4 of CYP2A6*1 (wild type) gene were determined by polymerase chain reaction (PCR) in 54 volunteers. Addiction to tobacco was evaluated using the Fagerström Test. The association between the presence of allelic variants of CYP2A6 and smoking and tobacco dependence was evaluated with chi square test. Results: The prevalence of *1, *2 (wt/*2), *3 (wt/*3 or *3/*3) and *4 (del/del) were 92.6%, 3.7%, 0% y 3.7%, respectively. No signifi cant association was observed between being a carrier of a variant genotype of CYP2A6 and smoking or tobacco dependence. Conclusions: In this sample of Chilean individuals we did not fi nd a relation between any
Relation of genetic variants of CYP2A6 with tobacco dependence and smoking habit in Chilean subjects. A pilot study Variantes genéticas de CYP2A6 y su relación con la dependencia tabáquica y el hábito de fumar en una muestra individuos chilenos. Un estudi