Absolute eosinophils count as a marker of mortality in patients with severe sepsis and septic shock in an intensive care unit
Author
dc.contributor.author
Merino, Carlos Adolfo
Author
dc.contributor.author
Martínez, Felipe Tomás
Author
dc.contributor.author
Cardemil Morales, Felipe
Author
dc.contributor.author
Rodríguez, José Ramón
Admission date
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2019-03-11T13:19:30Z
Available date
dc.date.available
2019-03-11T13:19:30Z
Publication date
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2012
Cita de ítem
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Journal of Critical Care, Volumen 27, Issue 4, 2018, Pages 394-399
Identifier
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08839441
Identifier
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15578615
Identifier
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10.1016/j.jcrc.2011.10.010
Identifier
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https://repositorio.uchile.cl/handle/2250/165635
Abstract
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Introduction: Eosinophils in the circulating blood undergo apoptosis during sepsis syndromes induced by the action of certain cytokines. Objective: The aim of the study was to evaluate the absolute eosinophils count (EC) as a marker of mortality in severe sepsis and septic shock. Patients and Method: A prospective cohort study of patients with a diagnosis of sepsis or septic shock admitted to the intensive care unit (ICU) of the Dr Gustavo Fricke Hospital between January 2008 and December 2009 was conducted. Daily EC in all patients was analyzed. Receiver operating characteristic curve analysis was used to assess the performance of the diagnostic test. Results: We studied a total of 240 patients. The median age was 62 years (interquartile range [IQR], 48-72 years), and 67 (27.9%) died. The median EC in patients who died was 43 (IQR, 14-121), whereas in surviving patients, it was 168 (IQR, 98-292) (P < .001). When the EC on the fifth day of hospital stay was assessed, an area under the