Identification of coli surface antigen 23, a novel adhesin of enterotoxigenic Escherichia coli
Author
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Del Canto, Felipe
Author
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Botkin, Douglas J.
Author
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Valenzuela, Patricio
Author
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Popov, Vsevolod
Author
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Ruiz-Perez, Fernando
Author
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Nataro, James P.
Author
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Levine, Myron M.
Author
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Stine, O. Colin
Author
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Pop, Mihai
Author
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Torres, Alfredo G.
Author
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Vidal, Roberto
Admission date
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2019-03-11T13:19:31Z
Available date
dc.date.available
2019-03-11T13:19:31Z
Publication date
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2012
Cita de ítem
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Infection and Immunity, Volumen 80, Issue 8, 2018, Pages 2791-2801
Identifier
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00199567
Identifier
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10985522
Identifier
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10.1128/IAI.00263-12
Identifier
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https://repositorio.uchile.cl/handle/2250/165646
Abstract
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Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea, mainly in developing countries. Although there are 25 different ETEC adhesins described in strains affecting humans, between 15% and 50% of the clinical isolates from different geographical regions are negative for these adhesins, suggesting that additional unidentified adhesion determinants might be present. Here, we report the discovery of Coli Surface Antigen 23 (CS23), a novel adhesin expressed by an ETEC serogroup O4 strain (ETEC 1766a), which was negative for the previously known ETEC adhesins, albeit it has the ability to adhere to Caco-2 cells. CS23 is encoded by an 8.8-kb locus which contains 9 open reading frames (ORFs), 7 of them sharing significant identity with genes required for assembly of K88-related fimbriae. This gene locus, named aal (adhesion-associated locus), is required for the adhesion ability of ETEC 1766a and was able to confer this adhesive phenotype to a nonadherent E. coli HB101 stra