Nuclear factor-kappaB: A main regulator of inflammation and cell survival in endometriosis pathophysiology
Author | dc.contributor.author | González-Ramos, Reinaldo | |
Author | dc.contributor.author | Defrère, Sylvie | |
Author | dc.contributor.author | Devoto, Luigi | |
Admission date | dc.date.accessioned | 2019-03-11T13:19:36Z | |
Available date | dc.date.available | 2019-03-11T13:19:36Z | |
Publication date | dc.date.issued | 2012 | |
Cita de ítem | dc.identifier.citation | Fertility and Sterility, Volumen 98, Issue 3, 2018, Pages 520-528 | |
Identifier | dc.identifier.issn | 00150282 | |
Identifier | dc.identifier.issn | 15565653 | |
Identifier | dc.identifier.other | 10.1016/j.fertnstert.2012.06.021 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/165679 | |
Abstract | dc.description.abstract | Objective: To update, analyze, and summarize the literature concerning nuclear factor-kappaB (NF-κB) participation in endometriosis pathophysiology. Design: Review. Result(s): Nuclear factor-kappaB is physiologically activated in the human endometrium, showing variable activity. A cyclic p65-DNA binding pattern was shown in the endometrium of healthy women. This cyclic pattern was altered in the endometrium of patients with endometriosis. Nuclear factor-kappaB is basally activated in peritoneal endometriotic lesions, showing higher p65 activity in red endometriotic lesions than in black lesions. In vivo and in vitro studies show up-regulation of inflammation and cell proliferation and down-regulation of apoptosis by NF-κB activity. Iron overload has been shown in the pelvic cavity of endometriosis patients, and iron overload and oxidative stress activate NF-κB in macrophages, which have been shown to participate in the endometriosis-associated inflammatory reaction. Conclusion(s): Nucl | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Fertility and Sterility | |
Keywords | dc.subject | Apoptosis | |
Keywords | dc.subject | cell proliferation | |
Keywords | dc.subject | endometriosis | |
Keywords | dc.subject | endometrium | |
Keywords | dc.subject | inflammation | |
Keywords | dc.subject | iron | |
Keywords | dc.subject | macrophages | |
Keywords | dc.subject | nuclear factor-kappaB | |
Título | dc.title | Nuclear factor-kappaB: A main regulator of inflammation and cell survival in endometriosis pathophysiology | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI |
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