Leptin and IGF-I/II during the first weeks of life determine body composition at 2 years in infants born with very low birth weight
Author
dc.contributor.author
Hernández, María Isabel
Author
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Rossel, Katherine
Author
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Peña, Verónica
Author
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Cavada Chacón, Gabriel
Author
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Avila, Alejandra
Author
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Iñíguez Vila, Germán
Author
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Mericq, Verónica
Admission date
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2019-03-15T16:03:22Z
Available date
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2019-03-15T16:03:22Z
Publication date
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2012
Cita de ítem
dc.identifier.citation
Journal of Pediatric Endocrinology and Metabolism, Volumen 25, Issue 9-10, 2018, Pages 951-955
Identifier
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0334018X
Identifier
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21910251
Identifier
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10.1515/jpem-2012-0184
Identifier
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https://repositorio.uchile.cl/handle/2250/165823
Abstract
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Rapid early growth is associated with adverse metabolic outcome. The aim of this study was to determine whether there are differences in body composition (BC) between very-low-birth-weight preterm (VLBWPT) infants born appropriate for gestational age (AGA) and small for gestational age (SGA) and whether these differences relate to first-year growth. Twenty-six VLBWPT (15 AGA and 11 SGA). The BC was analyzed by dual X-ray absorptiometry at 2 years, and insulin-like growth factors (IGFs) I and II and leptin were administered weekly for 8 weeks and at 1, 3, 6, and 12 months. At 24 months, the VLBW SGA infants were lighter and had less peripheral fat and lean mass than VLBW AGA infants. In all patients, the percentage of fat mass correlated inversely with the change in weight [standard deviation scores (SDS)] from newborn to 2 and 4 weeks and the 1-month leptin and lean mass (SDS) correlated inversely with the change in weight (SDS) from newborn to 2, 4, and 8 weeks and with 4-week IGF-I a