Systemic Injection of Kainic Acid Differently Affects LTP Magnitude Depending on its Epileptogenic Efficiency
Author
dc.contributor.author
Suárez, Luz M.
Author
dc.contributor.author
Cid, Elena
Author
dc.contributor.author
Gal, Beatriz
Author
dc.contributor.author
Inostroza, Marion
Author
dc.contributor.author
Brotons-Mas, Jorge R.
Author
dc.contributor.author
Gómez-Domínguez, Daniel
Author
dc.contributor.author
de la Prida, Liset Menéndez
Author
dc.contributor.author
Solís, José M.
Admission date
dc.date.accessioned
2019-03-15T16:03:25Z
Available date
dc.date.available
2019-03-15T16:03:25Z
Publication date
dc.date.issued
2012
Cita de ítem
dc.identifier.citation
PLoS ONE, Volumen 7, Issue 10, 2018,
Identifier
dc.identifier.issn
19326203
Identifier
dc.identifier.other
10.1371/journal.pone.0048128
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/165830
Abstract
dc.description.abstract
Seizures have profound impact on synaptic function and plasticity. While kainic acid is a popular method to induce seizures and to potentially affect synaptic plasticity, it can also produce physiological-like oscillations and trigger some forms of long-term potentiation (LTP). Here, we examine whether induction of LTP is altered in hippocampal slices prepared from rats with different sensitivity to develop status epilepticus (SE) by systemic injection of kainic acid. Rats were treated with multiple low doses of kainic acid (5 mg/kg; i.p.) to develop SE in a majority of animals (72-85% rats). A group of rats were resistant to develop SE (15-28%) after several accumulated doses. Animals were subsequently tested using chronic recordings and object recognition tasks before brain slices were prepared for histological studies and to examine basic features of hippocampal synaptic function and plasticity, including input/output curves, paired-pulse facilitation and theta-burst induced LTP. Co