Pharmacokinetic considerations in critically ill patients Consideraciones farmacocinéticas en el paciente crítico
Author
dc.contributor.author
Escobar, Leslie
Author
dc.contributor.author
Gai, María Nella
Author
dc.contributor.author
Redueira, Tomás
Author
dc.contributor.author
Andresen, Max
Admission date
dc.date.accessioned
2019-03-15T16:03:32Z
Available date
dc.date.available
2019-03-15T16:03:32Z
Publication date
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2012
Cita de ítem
dc.identifier.citation
Revista Medica de Chile, Volumen 140, Issue 6, 2018, Pages 780-788
Identifier
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00349887
Identifier
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07176163
Identifier
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10.4067/S0034-98872012000600014
Identifier
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https://repositorio.uchile.cl/handle/2250/165848
Abstract
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Critically ill patients in Intensive Care Units (ICUs) are exposed to multiple procedures and usually require complex treatment regimens. Many of them suffer from comorbidities and different complications such as organ failure, drug-drug interactions, and unusual therapeutic interventions that can produce significant pathophysiologic changes. For that reason, pharmacokinetics for several substances is different to what is described for healthy patients, complicating drug selection and drug dosage to achieve appropriate effects. Low doses may determine a reduction of drug effectiveness and overdoses leading to toxicity. The aim of this paper is to review the pharmacokinetic considerations that must be considered when treating acute ICU patients.