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Authordc.contributor.authorHenríquez, Daniel R. 
Authordc.contributor.authorBodaleo, Felipe J. 
Authordc.contributor.authorMontenegro Venegas, Carolina 
Authordc.contributor.authorGonzález Billault, Christian 
Admission datedc.date.accessioned2019-03-15T16:03:40Z
Available datedc.date.available2019-03-15T16:03:40Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationPLoS ONE, Volumen 7, Issue 12, 2018,
Identifierdc.identifier.issn19326203
Identifierdc.identifier.other10.1371/journal.pone.0053123
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/165884
Abstractdc.description.abstractMicrotubule-associated protein 1B (MAP1B) is a neuronal protein involved in the stabilization of microtubules both in the axon and somatodendritic compartments. Acute, genetic inactivation of MAP1B leads to delayed axonal outgrowth, most likely due to changes in the post-translational modification of tubulin subunits, which enhances microtubule polymerization. Furthermore, MAP1B deficiency is accompanied by abnormal actin microfilament polymerization and dramatic changes in the activity of small GTPases controlling the actin cytoskeleton. In this work, we showed that MAP1B interacts with a guanine exchange factor, termed Tiam1, which specifically activates Rac1. These proteins co-segregated in neurons, and interact in both heterologous expression systems and primary neurons. We dissected the molecular domains involved in the MAP1B-Tiam1 interaction, and demonstrated that pleckstrin homology (PH) domains in Tiam1 are responsible for MAP1B binding. Interestingly, only the light chain 1 (
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePLoS ONE
Keywordsdc.subjectAgricultural and Biological Sciences (all)
Keywordsdc.subjectBiochemistry, Genetics and Molecular Biology (all)
Keywordsdc.subjectMedicine (all)
Títulodc.titleThe Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B) Is Responsible for Tiam1 Binding and Rac1 Activation in Neuronal Cells
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile