Boron as testicular toxicant in mice (Mus domesticus) El Boro como Tóxico Testicular en Ratón (Mus domesticus)
Author
dc.contributor.author
Bustos-Obregón, Eduardo
Author
dc.contributor.author
Olivares, Christopher
Admission date
dc.date.accessioned
2019-03-15T16:04:14Z
Available date
dc.date.available
2019-03-15T16:04:14Z
Publication date
dc.date.issued
2012
Cita de ítem
dc.identifier.citation
International Journal of Morphology, Volumen 30, Issue 3, 2018, Pages 1106-1114
Identifier
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07179367
Identifier
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07179502
Identifier
dc.identifier.other
10.4067/S0717-95022012000300057
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/165917
Abstract
dc.description.abstract
It has been reported that boron causes changes in various systems, including the male reproductive system. Residents in some towns in northern Chile were consuming a few years ago in the drinking water 20 times more than the amount established as permissible limit by WHO. This study evaluates the effects in an animal model of high intake of boron on the testis. Boron was administered in the drinking water. Twenty male mice (Mus domesticus), sexually mature, were used, divided into 2 groups: the experimental group was given Boron at a dose of 12 mg/L, and the control group 0.6 mg/L, for 42 days. Sections of testis were obtained for: HE staining (Morphometry and Histopathology), Immunohistochemistry (Cox-2), Mallory and Picrosirious stain (evaluation of tunica albuginea). The results indicate that ingestion of a dose of 12 mg Boron/L produces vacuolization, tubular epithelial desquamation and tamponade. Morphometry revealed decreased tubular diameter and epithelial height and lumen diame