Enhanced skeletal muscle lipid oxidative efficiency in insulin-resistant vs insulin-sensitive nondiabetic, nonobese humans
Author
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Galgani Fuentes, José
Author
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Vásquez, Karla
Author
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Watkins, Guillermo
Author
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Dupuy, Aude
Author
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Bertrand-Michel, Justine
Author
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Levade, Thierry
Author
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Moro, Cedric
Admission date
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2019-03-15T16:04:22Z
Available date
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2019-03-15T16:04:22Z
Publication date
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2013
Cita de ítem
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Journal of Clinical Endocrinology and Metabolism, Volumen 98, Issue 4, 2018,
Identifier
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0021972X
Identifier
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19457197
Identifier
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10.1210/jc.2012-3111
Identifier
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https://repositorio.uchile.cl/handle/2250/165954
Abstract
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Context: Skeletal muscle insulin resistance is proposed to result from impaired skeletal muscle lipid oxidative capacity. However, there is no evidence indicating that muscle lipid oxidative capacity is impaired in healthy otherwise insulin-resistant individuals. Objective: The objective of the study was to assess muscle lipid oxidative capacity in young, nonobese, glucose-tolerant, insulin-resistant vs insulin-sensitive individuals. Design and Volunteers: In 13 insulin-sensitive [by Matsuda index (MI) (22.6 ± 0.6 [SE] kg/m2); 23 ± 1 years; MI 5.9 ± 0.1] and 13 insulin-resistant (23.2 ± 0.6 kg/m2;23 ± 3 years; MI 2.2 ± 0.1) volunteers, skeletal muscle biopsy, blood extraction before and after an oral glucose load, and dual-energy x-ray absorptiometry were performed. Main Outcome Measures: Skeletal muscle mitochondrial to nuclear DNA ratio, oxidative phosphorylation protein content, and citrate synthase and β-hydroxyacyl-CoA dehydrogenase activities were assessed. Muscle lipids and palm