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Authordc.contributor.authorParra, Valentina 
Authordc.contributor.authorVerdejo, Hugo E. 
Authordc.contributor.authorIglewski, Myriam 
Authordc.contributor.authorDel Campo, Andrea 
Authordc.contributor.authorTroncoso, Rodrigo 
Authordc.contributor.authorJones, Deborah 
Authordc.contributor.authorZhu, Yi 
Authordc.contributor.authorKuzmicic Previtali, Jovan Paolo 
Authordc.contributor.authorPennanen, Christian 
Authordc.contributor.authorLópez Crisosto, Camila 
Authordc.contributor.authorJaña, Fabián 
Authordc.contributor.authorFerreira, Jorge 
Authordc.contributor.authorNoguera, Eduard 
Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorBernlohr, David A. 
Authordc.contributor.authorKlip, Amira 
Admission datedc.date.accessioned2019-03-15T16:05:51Z
Available datedc.date.available2019-03-15T16:05:51Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationDiabetes, Volumen 63, Issue 1, 2018, Pages 75-88
Identifierdc.identifier.issn00121797
Identifierdc.identifier.issn1939327X
Identifierdc.identifier.other10.2337/db13-0340
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/166065
Abstractdc.description.abstractInsulin regulates heart metabolism through the regulation of insulin-stimulated glucose uptake. Studies have indicated that insulin can also regulate mitochondrial function. Relevant to this idea, mitochondrial function is impaired in diabetic individuals. Furthermore, the expression of Opa-1 and mitofusins, proteins of the mitochondrial fusion machinery, is dramatically altered in obese and insulin-resistant patients. Given the role of insulin in the control of cardiac energetics, the goal of this study was to investigate whether insulin affects mitochondrial dynamics in cardiomyocytes. Confocal microscopy and the mitochondrial dye MitoTracker Green were used to obtain three-dimensional images of the mitochondrial network in cardiomyocytes and L6 skeletal muscle cells in culture. Three hours of insulin treatment increased Opa-1 protein levels, promoted mitochondrial fusion, increased mitochondrial membrane potential, and elevated both intracellular ATP levels and oxygen consumption in
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceDiabetes
Keywordsdc.subjectInternal Medicine
Keywordsdc.subjectEndocrinology, Diabetes and Metabolism
Títulodc.titleInsulin stimulates mitochondrial fusion and function in cardiomyocytes via the AktmTOR-NFkB-Opa-1 signaling pathway
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile