Melatonin protective role in mouse cauda epipidymal spermatozoa damage induced by sodium arsenite Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio
Author
dc.contributor.author
Bustos-Obregón, Eduardo
Author
dc.contributor.author
Poblete, Daniel
Author
dc.contributor.author
Catriao, Roberto
Author
dc.contributor.author
del Sol, Mariano
Author
dc.contributor.author
Fernandes, Fábio Henrique
Admission date
dc.date.accessioned
2019-03-15T16:06:02Z
Available date
dc.date.available
2019-03-15T16:06:02Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
International Journal of Morphology, Volumen 31, Issue 4, 2018, Pages 1251-1256
Identifier
dc.identifier.issn
07179367
Identifier
dc.identifier.issn
07179502
Identifier
dc.identifier.other
10.4067/S0717-95022013000400017
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/166098
Abstract
dc.description.abstract
We evaluated the sperm parameters such as cauda epididymis weight, sperm count, sperm morphology and sperm DNA stability of adult CF-1 male mice treated daily (oral exposure) with the toxic sodium arsenite (As, 7.0 mg/kg/body weight); Melatonin (Me, 10.0 mg/kg/bw), Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw) and Negative Control (NaCl 0.9%) to assess acute (8.3 days), chronic (33.2 days) and recovery of testicular damage (66.4 days). Arsenic decreases the number of sperm from chronic treatment (33.2 days) and this effect continued until 66.4 days of treatment. The toxic effect of As also altered the morphology of spermatozoa in all treatment periods when compared to the negative control group. However, Metalonin induced protective effects in periods of 33.2 and 66.4 days of treatment. Additionally, the stability of DNA was significantly affected by arsenic in all periods, but the chronic treatment (33.2 days) in the AsMe revealed increased stability compared to the group treated with ars
Melatonin protective role in mouse cauda epipidymal spermatozoa damage induced by sodium arsenite Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio