Physicochemical characterization and cytotoxic studies of nonionic surfactant vesicles using sucrose esters as oral delivery systems
Author
dc.contributor.author
Valdés, Karina
Author
dc.contributor.author
Morilla, María José
Author
dc.contributor.author
Romero, Eder
Author
dc.contributor.author
Chávez, Jorge
Admission date
dc.date.accessioned
2019-03-15T16:06:04Z
Available date
dc.date.available
2019-03-15T16:06:04Z
Publication date
dc.date.issued
2014
Cita de ítem
dc.identifier.citation
Colloids and Surfaces B: Biointerfaces, Volumen 117,
Identifier
dc.identifier.issn
18734367
Identifier
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09277765
Identifier
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10.1016/j.colsurfb.2014.01.029
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/166107
Abstract
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Several nanotechnological solutions for mucosal immunization have been proposed, such as nanoparticles, liposomes, solid lipidic particles, micelles, and surfactant vesicles. In recent years, surfactant vesicles have gained increasing scientific attention as an alternative potential drug delivery system to the conventional liposome. This type of vesicle known as niosomes or nonionic surfactant vesicles (NSVs) has a structure and properties similar to those of liposomes. Both of them can transport hydrophilic drugs by encapsulation in the aqueous inner pool or hydrophobic drugs by intercalation into hydrophobic domains. The aim of this study was to prepare and characterize vesicles formed by sucrose esters as protective systems of bioactive molecules for oral administration. Vesicles were prepared using two commercial products formed by mixtures of mono and diesters S-570 and S-770, respectively. Determined parameters were size and zeta potential; the stability of formulations was teste